|
Kichenin K, Decollogne S, Angignard J, Seman M. Cardiovascular
and pulmonary response to oral administration of ATP in rabbits. J
Appl Physiol. 2000;Jun;88(6):1962-1968.
Groupe d'Immunologie Denis Diderot, Universite Paris 7, CP7124,
75251 Paris Cedex 05, France.
Extracellular purines such as ATP and adenosine participate in the regulation
of cardiovascular and respiratory functions through specific P1 and P2
purine receptors. These properties have mainly been described after intravenous
infusion. Experiments reported herein were designed to explore the possible
effect of oral ATP administration (3 or 20 mg. kg(-1). day(-1)) on vascular,
cardiac, and pulmonary functions in rabbits. Whereas a unique oral dose
of ATP has no effect, chronic supplementation during 14 days reduces
peripheral vascular resistance, pulmonary resistance, and respiratory
frequency and increases arterial PO(2). No effect on central blood pressure
and heart rate is observed, but an increase of the left ventricular work
index is noticed subsequent to the diminution of vascular resistance.
Rather similar cardiovascular modifications are observed in rabbits given
20 mg. kg(-1). day(-1) adenosine for 14 days but without variation of
respiratory parameters. These original effects of repeated oral treatment
with ATP may result from an adaptive metabolic response to nucleoside
supplementation that might affect the turnover of extracellular purines
leading to P1- and/or P2-receptor activation.
|
Abstracts