Abstracts

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Wang Jingqing, BU Guoxuan. Clinical observation of oral adenosine triposthate in treating rhinitis medicamentosa. Chinese Medical Journal, 2000;113(4):349.

Wang Jingqing, Department of Otolaryngology, Zhuhai Municipal People’s Hospital, Zhuhai 519000, China; BU Guoxuan. Department of Otolaryngology, The Third Clinical College, Norman Bethuen University of Medical Sciences, Changchun 130031, China.

Objective: To observe the effect on the patients with rhinitis medicamentosa treated by oral adenosine triposthate (ATP).

Methods: There were 150 cases with rhinitis medicamentosa, who had prolonged use of nasal drops of vasoconstricators, such as privine for one month to more than ten years. All cases were due to chronic tonsillitis caused by adenoid hypertrophy, "coryza", allergic rhinitis, deviation of nasal septum, polyp of sinus and sinusitis, and vasomoter rhinitis. Of them, 87 were males and 63 females, aged 5-53 years. After original disease treated, 103 patients were given oral ATP tablets 40 mg three times a day for three days or one week at most, and then compared with the rest 47 patients (controls) treated by nasal drops of dexamethazone of 0.25 mg/ml dilution for 1-2 weeks then given normal saline only. The effects on the experimental group of taking ATP and contrast group of using dexamethazone were determined subjectively by patients' symptoms and objectively by rhinomanomoter of Mastre PF-2001. The investigation lasted eight weeks.

Results: Patients in the experimental group showed improvement at the beginning several hours to three days after the treatment. Rhinomanometer studies indicated the nasal resistance in 94 cases out of the 103 dropped to more than 50%, with an improved rate of 91.2%. The swollen inferior turbinates became shrunk. The color of the mucosa turned from dark purple to pink. While the time of improvement in the contrast group began at least one week after the treatment. The obvious improvement was shown after 2-3 weeks, and disappearance of symptoms, after 4-8 weeks. The improvement rate was 81%.

Conclusion: The symptoms of rhinitis medicamentosa can be quickly and effectively improved by taking ATP.