PRODUCT DESCRIPTION
What is ATP?
ATP is an abbreviation for adenosine 5'-triphosphate, commonly known
as "the universal energy
storage molecule." ATP exists both inside (intracellularly) and outside
(extracellularly) virtually
every cell of the body. The role of intracellular ATP has been well established
— it is largely
responsible for the energetics, function and survival of cells. When the
phosphate bonds of ATP
are broken down, the energy released powers all body functions. Extracellular
ATP regulates
many physiological responses — such as vascular, cardiac and muscle
functions
— by interacting
with specific ATP receptors on cell surfaces. Interestingly, when intracellular
ATP becomes
depleted, extracellular ATP can cross into cells via its catabolic components,
adenosine and
inorganic phosphate. While ATP is generally manufactured in the body on
a continual basis, age,
exercise and other stressors can significantly reduce or deplete its levels.
Through an exclusive license agreement with Dr. Eliezer Rapaport, a widely
recognized expert in
adenosine nucleotides, Technical Sourcing International, Inc. (TSI) is
the only company to
manufacture patented ATP as a novel nutraceutical ingredient.
What
does PEAK ATP® do?
TSI's patented PEAK ATP elevates the body's extracellular ATP
levels. Scientific evidence has
demonstrated that extracellular ATP is a major regulator of vascular, cardiac
and muscle
functions. By activating specific ATP receptors present on vascular endothelial
cells (the cells that
line the blood vessel walls), ATP improves blood vessel tone and increases
vasodilation, which
reduces pulmonary and systemic vascular resistance (the resistance of the
vessels to blood flow).
These actions stimulate blood flow to peripheral areas without affecting
blood pressure or heart
rate.
Not only is exogenous ATP cardioprotective, but it also enhances the delivery
of glucose,
nutrients and oxygen to working and recovering muscles. Additionally, it
helps remove catabolic
waste products. These mechanisms improve physical performance, benefit
muscle growth,
strength and recovery, and increase overall energy levels. What's more,
increases in extracellular
ATP have also been demonstrated to enhance cerebral blood flow and metabolism
— boosting
mental acuity and potentially lessening the perception of fatigue and/or
exercise-associated pain.
Other products on the market claim to increase
ATP levels. What makes PEAK ATP
unique?
Dietary supplements currently available and claiming to enhance
physiological ATP synthesis —
such as creatine, coenzyme Q10, pyruvate, and ribose — have never been
demonstrated
experimentally to elevate intracellular or extracellular ATP levels. Only
the exogenous
administration of ATP itself has been shown to effectively elevate ATP
levels and provide the
associated physiological benefits.
Decades of exhaustive research by Dr. Eliezer Rapaport, considered one
of the world's foremost
authorities on ATP, have resulted in a unique portfolio of ATP patents.
Based on his landmark
research and expertise, TSI can now introduce the first legitimate entry
of ATP into the
supplement marketplace. TSI's PEAK ATP is the only ATP clinically
tested to demonstrate its
effectiveness, and the only ATP backed by Dr. Rapport's research and patents.
TSI has also
developed both domestic and foreign patent-pending ATP technology specifically
for the
administration of our ATP formulation in reducing muscle fatigue and enhancing
human
performance.
SCIENTIFIC EVIDENCE & SAFETY
What data exists to show PEAK
ATP is efficacious?
Studies on cells, animals and humans suggest that exogenous administration
of ATP increases
the circulation to peripheral sites. Increased blood flow has a host of
benefits, since blood is the
delivery source of glucose, nutrients and oxygen for tissues. Research
shows that PEAK ATP can
elevate the body's extracellular ATP levels, making it effective for a
variety of indications, such as
energy, athletic performance and anti-aging. In fact, several published
human studies in which
ATP was administered intravenously have reported significant physiological
and metabolic
improvements. Pioneering animal studies have shown that chronic oral administration
of ATP
produces notable beneficial alterations in the host's physiology, including
improvements in muscle
metabolism, increases in peripheral blood flow and blood oxygenation.
How
does PEAK ATP elevate the body's extracellular ATP levels?
After ingestion,
PEAK ATP is broken down into adenosine and inorganic phosphate. Following
rapid absorption by the gut, these compounds are incorporated into and
expand the body's liver
ATP pools. Detailed experimental animal studies have demonstrated that
the turnover of the
expanded liver ATP pools supply the necessary precursor, adenosine, for
red blood cell ATP
synthesis. In sum, exogenously administered ATP elevates liver ATP pools,
which in turn yields
elevated red blood cell ATP pools. Subsequently, the expanded red blood
cell ATP pools are
slowly released into the blood plasma (extracellular). Animal and human
studies have both
conclusively shown that oral administration of ATP elevates ATP levels
in liver, red blood cells and
blood plasma.
Are these extracellular ATP levels measurable?
Yes. Research has shown that when PEAK ATP is taken orally, it enters
the blood and creates a
measurable increase in circulating ATP levels for at least six hours. Analyses
to determine red
blood cell levels of ATP are complex and require special equipment and
procedures. TSI has
partnered with Dr. Edward Abraham, the inventor of specific methods used
to measure circulating
ATP concentrations (patent pending), in order to convincingly demonstrate
PEAK ATP's effect on
circulating ATP in clinical settings.
These methods include utilizing a Packard Instrument Company 12-detector
luminometer to
perform the firefly luciferase assay. The luciferin/luciferase reaction
assay has a threshold for ATP
detection in the subnanomolar concentration range.
Is it possible
to trace the path of orally administered ATP?
Yes. Mechanistic and pharmacokinetic studies have been conducted with
radioactively-labeled
ATP in mice to establish the bioavailability of orally administered ATP,
to define the path of the
ATP in the body and to establish pharmacokinetic parameters such as half-life,
clearance and
volume of distribution.
How safe is PEAK ATP?
PEAK ATP is not a stimulant. It does not affect heart rate nor does
it increase blood pressure.
In fact, no adverse side effects whatsoever have been observed in the pilot
studies and human
trials conducted with PEAK ATP.
An LD 50 Acute Toxicity Study, commissioned by TSI and performed at the
Shanghai Institute of
Materia Medica (SIMM), demonstrated that PEAK ATP is safe and non-toxic.
In the experiment,
PEAK ATP was given to rats at doses as high as 15.0 g/kg body weight,
and produced no
toxicity, mortality or adverse reactions. Likewise, research investigating
the active compound in
PEAK ATP has concluded it is a safe and non-toxic as well.
Is there
any doping test risk for athletes using PEAK ATP?
No. ATP does not appear on any prohibited substance list, and TSI has
consulted the
International Olympic Committee to confirm the ingredient's standing. Because
body stores of
ATP can only be increased to certain levels, use of the ingredient as a
dietary supplement does
not fit the definition of doping.
USAGE, STORAGE & STABILITY
What is the suggested dose for PEAK
ATP and how should it be taken?
TSI's recent clinical work suggests the greatest efficacy of PEAK ATP
is achieved when two (2)
125 mg doses of PEAK ATP's active compound, ATP disodium, are taken per
day. TSI suggests
administration of one (1) dose of 125 mg in the morning and one dose (1)
of 125 mg in the
afternoon, both on an empty stomach.
Is that a sufficient dose for
weighing 170 pounds or more?
Yes. Research conducted to date has focused on athletes weighing approximately
190 pounds.
While no clinical data exists to demonstrate better efficacy with higher
dosing, individual weight
and metabolism will vary. Some variation in dosage may be necessary to
find the dose that
yields the best individual results.
Can other products be used in
combination with PEAK ATP?
Use of other ingredients or products with PEAK ATP is neither encouraged
nor discouraged, but
because of PEAK ATP's ability to enhance blood flow, it may help the physiological
distribution
of other products or ingredients within the body. There is no scientific
reason to believe that
PEAK ATP would hinder the effectiveness of any established dietary supplement
product or
program.
How is PEAK ATP manufactured?
PEAK ATP is produced through a proprietary fermentation process in
a GMP facility — the only
one in China producing nucleosides and nucleotides on a large scale — that
conforms to ISO9002
standards. PEAK ATP is manufactured according to TSI's exact specifications
and subjected to
rigorous in-house physical, analytical (including HPLC) and microbial testing.
Because ATP is
subject to some degradation by stomach acids, this material must be formulated
to exacting
specifications for solid dose delivery products. TSI works closely with
our manufacturing licensees
to ensure the proper technology is utilized in order to enhance the absorption
of ATP into the
bloodstream and provide maximum bioavailability for intended applications.
What
specific technology is used to ensure the absorption of PEAK ATP in solid
dose
delivery forms?
Most dietary supplements are designed to release their contents into
the stomach. In the
presence of acid, however, ATP administered in a solid dose delivery form
is subject to
degradation. To prevent stomach acid from compromising the PEAK ATP in
its solid form, we
make sure that a protective barrier is utilized. This prevents the breakdown
of the compound in
the stomach, so that PEAK ATP's active principals, adenosine and inorganic
phosphate, are
released and absorbed intact.
How is this different from the way other
ATP products are offered?
TSI holds an exclusively licensed suite of issued patents and patent-pending
applications for oral
ATP administration. We also have our own domestic and foreign patent-pending
technology. Any
company that uses an ATP ingredient, other than PEAK ATP, in its products
is infringing on
TSI's exclusive patents. It's no surprise, then, that the majority of companies
offering ATP in their
products do not use or specialize in the specific manufacturing processes
needed to protect this
fragile compound in its solid dose delivery form. What's more, they may
not subject their
products to rigorous quality assurance testing methods required of all
PEAK ATP licensees. All
PEAK ATP licensees' products are manufactured under strict quality controls.
TSI requires that
our licensees test their products for a specific dissolution, using current
USP methods and
conduct post-manufacturing ATP assays using HPLC technology.
How should
PEAK ATP be stored?
TSI has detected no degradation of PEAK ATP during the course of our
raw material stability
tests. As provided to dietary supplement manufacturers, the ingredient
has a two-year shelf life,
as long as its containers remain unopened and are kept under optimal conditions.
Capsules and tablets containing PEAK ATP should always be stored in cool,
dry conditions and
used prior to the expiration date.
OTHER GENERAL QUESTIONS
Is ATP only good for anaerobic forms of
exercise?
No. While some supplements are only associated with assisting explosive
power sports like weight
lifting and sprinting, ATP is inherently involved in far more body processes
than just muscle
contractions. Its extracellular roles produce a multitude of physiological
benefits that ultimately
assist in aerobic forms of exercise too.
Will PEAK ATP inhibit the
body's ability to produce ATP naturally?
No. While PEAK ATP is capable of elevating or restoring organ, red
blood cell and blood plasma
ATP pools in humans to their normal levels, exogenous administration of
ATP could never take
the place of metabolically generated ATP. Where there is no ATP, there
is no life.
Do only bodybuilders realize the benefits from taking
PEAK ATP?
No. Anyone who is interested in greater energy levels or enhanced athletic
performance can
benefit from taking PEAK ATP. PEAK ATP additionally has distinct benefits
for anyone
experiencing the effects of aging, as it supports cardiovascular health,
vascular functions, and
mental acuity by increasing circulation.
How long does it take to
attain benefits from PEAK ATP?
Several human pilot and animal studies indicate that cardiovascular,
circulatory and vascular
system benefits are realized almost immediately upon taking the ingredient.
Logging statistically
significant performance results, however, requires chronic dosing for at
least two weeks.
Download Frequently Asked Questions Sheet
TOP OF PAGE
|
Frequently
Asked Questions