A systematic review and meta-analysis found that adenosine triphosphate (ATP) supplementation led to significant improvements in maximal strength compared to a placebo, particularly in resistance-trained men at doses of 400 mg/day. Moreover, daily intake of 400 mg of ATP for up to 12 weeks was deemed safe for healthy individuals.
The aim of the research was to examine how a single dose of disodium Adenosine Triphosphate (ATP) affects muscular performance in trained adults. In this acute, crossover, randomized, double-blind, placebo-controlled study, 18 trained males were enlisted to perform a series of strength tests following supplementation with either 400 mg of PEAK ATP® or a placebo. While acute supplementation didn’t yield notable enhancements in muscle strength indicators, it did demonstrate a reduction in fatigue levels over the course of the exercise, resulting in improved performance endurance.
The study examined the acute effect of PEAK ATP® vs. placebo on cognitive function, reaction time, multiple object tracking and mood in healthy men and women before and after a fatiguing exercise protocol.
In this placebo-controlled crossover study 20 adults that were healthy, recreationally active individuals between ages 18-40 participated in the 14-day study. Subjects were given PEAK ATP® or placebo to ingest before performing an all-out three-minute sprint test on a cycle erometer (3MT).
Researchers measured visuomotor reaction time, multiple object tracking speed, mood and cognition before and after participants’ high-intensity exercise bouts. Researchers found that subjects supplementing with PEAK ATP® maintained proactive reaction time and improved reactive reaction time following a high-intensity sprint exercise. The study also showed that PEAK ATP® supplementation was able to decrease the number of errors during a reactive visuomotor task. It also suggested that ATP may mitigate exercise induced cognitive dysfunction.
The goal of this study was to examine the acute effect of PEAK ATP® supplementation on performance and physiological responses during resistance exercise in recreationally trained men. In a randomized, double-blind study, 11 trained male subjects were given PEAK ATP® (400 mg) or a placebo supplement. Each subject completed 3 experimental trials where they completed sets of half-squats until reaching momentary muscular failure (fatigue). An acute dose of PEAK ATP® supplementation improved the number of repetitions performed as well as oxygen consumption and energy expenditure during exercise. This study suggests that supplementing with PEAK ATP® prior to a fatiguing, high volume lower body training session can enhance lifting performance.
In a double-blind, placebo-controlled, randomized design study, 42 healthy, trained men were given either 400 mg of PEAK ATP® or a placebo for 2 weeks. A repeated sprint exercise test was performed before and after the supplementation period. During the sprint bout, muscle activation and excitability, and power were measured. Oral PEAK ATP® supplementation prevented exercise-induced declines in ATP and its metabolites. PEAK ATP® supplementation also enhanced peak power and muscular excitability. This study suggests PEAK ATP® supplementation would be beneficial for sports requiring repeated high-intensity sprinting bouts.
Twelve college-aged, resistance-trained male subjects took 400 mg of PEAK ATP® daily, either before breakfast or 30 minutes prior to exercise. Vasodilation and blood flow were measured in the brachial artery by ultrasound before exercise and at 0, 3, and 6 minutes after performing acute arm exercise (30 sets of 20 contractions at 50% 1-RM). This study demonstrates the ability of PEAK ATP® to improve muscle blood flow during and/or after exercise, which may enhance the delivery of oxygen and nutrients to the muscle as well as waste removal from the muscle.
A double-blind, placebo-controlled, human crossover study assessed the muscle performance-enhancing effects of 400 mg of PEAK ATP® (200 mg twice daily) on healthy, active adults. Sixteen male and female participants were randomized to receive either PEAK ATP® or placebo for 15 days. Before and after each supplementation period, each participant completed a muscle strength and fatigue test consisting of three sets of 50 maximal knee extensions. After a one-week washout period, the groups were switched, so that those who had been taking placebo now took PEAK ATP® and vice versa. PEAK ATP® improved participants’ ability to maintain force output during an exhaustive exercise bout and tended to reduce muscle fatigue.
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